Publications

HAL Open Archives: https://hal.utc.fr/GEC/en

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Articles

Merlier F., Octave S., Tse Sum Bui B., Thomasset B. Evaluation of Performance and Validity Limits of Gas Chromatography electron ionization – Orbitrap Detector for fatty acid methyl esters analyses . Rapid Commun Mass Spectrom2019, in press,.
 

Medina Rangel P., Moroni E., Merlier F., Gheber L., Vago R., Tse Sum Bui B., Haupt K. Chemical Antibody Mimics Inhibit Cadherin-Mediated Cell-Cell Adhesion: A Promising Strategy for Cancer Therapy. Angewandte Chemie2019, In press ,.
 

Paruli E Iii., Griesser T., Merlier F., Gonzaro C., Haupt K. Molecularly imprinted polymers by thiol–yne chemistry: making imprinting even easier. Polymer Chem. 2019, 10,4732-4739.
 

Franche A., Imbs C., Fayeulle A., Merlier F., Billamboz M. Léonard E. Zinc-mediated reactions on salicylaldehyde for Botrytis cinerea control . Chinese Chemical Letters 2019, In press ,.
 

Martins-noguerol R., Moreno-pérez Aj., Acket S., Makni S., Garcés R., Troncoso-ponce A., Salas Jj., Thomasset B., Martínez-force E. Lipidomic Analysis of Plastidial Octanoyltransferase Mutants of Arabidopsis thaliana . Metabolites 2019, 9(10) ,209 .
 

Rondeau M., Esmaeel Q., Crouzet J., Blin Pauline., Gosselin I., Sarazin C., Pernes M., Beugrand J., Wisniewski-dyé F., Vial L., Faure D. Clément C., Ait Barka E., Jacquard C. Sanchez L. Biofilm constructing variants of Paraburkholderia phytofirmans PsJN outcompete the wild-type form in free-living and static conditions but not in planta . Applied and Environmental Microbilogu 2019, 85 ,e02670-18 .
 

Araya-farias M., Husson E., Saavedra-torrico J., Gérard D., Roulard R., Gosselin I., Rakotoarivonina H., Lambertyn V. Rémond C. Sarazin C. Wheat Bran Pretreatment by Room Temperature Ionic Liquid-Water Mixture: Optimization of Process Conditions by PLS-Surface Response Design . Fontiers in Chemistry 2019, 7 ,585.
 

Husson E., Hulin L., Hadad C., Boughanmi C., Stevanovic T., Sarazin C. Acidic Ionic Liquid as Both Solvent and Catalyst for Fast Chemical Esterification of Industrial Lignins: Performances and Regioselectivity . Fontiers in Chemistry 2019, 7 ,578.
     ABSTRACT: 

Alayoubi R., Mehmood N., Husson E., Kouzayha A., Tabcheh M., Chaveriat L, Sarazin C., Gosselin I. Low temperature ionic liquid pretreatment of lignocellulosic biomass to enhance bioethanol yield . Renewable Energy 2019, 145 ,1808-1816 .
 

Mier A., Nestora S., Medina Rangel P., Rossez Y., Haupt K., Tse Sum Bui B. Cytocompatibility of Moleculary Imprinted Polymers for Deodorants : Evaluation on Human Keratinocytes and Axillary-Hosted Bacteria . ACS Appl. Mater. Interfaces 2019, 2 ,3439-3447    ABSTRACT: https://doi.org/10.1021/acsabm.9b00388

Le Priol L., Dagmey A., Morandat S., Saleh K., El Kirat K., Nesterenko A. Comparative study of plant protein extracts as wall materials for the improvement of the oxidative stability of sunflower oil by microencapsulation. Food Hydrocolloids2019, 95,105-115.
 

Monnier N., Furlan A-l., Buchoux S., Deleu M., Dauchez M., Rippa S., Sarazin C. Exploring the Dual Interaction of Natural Rhamnolipids with Plant and Fungal Biomimetic Plasma Membranes through Biophysical Studies" has been published in IJMS as part of the Special Issue SAR "Out of the Box. Int. J. Mol. Sci.2019, 20,1009.
 

Medina Rangel P., Caclef S., Xu J., Panagiotopoulou M., Kovensky J., Tse Sum Bui B., Haupt K. Solid-phase synthesis of moleculary imprinted polymer nanolabels: Affinity tools for cellular bioimaging of glycans. Scientific Reports2019, 9,3923.
 

Fahs Z., Rossez Y., Guénin S., Gutierrez L., Thomasset B., & Perrin, Y. Cloning and molecular characterization of three lysophosphatidic acid acyltransferases expressed in flax seeds. Plant Science2019, 280,41-50.
 

Xu J., Merlier F., Avalle B., Veillard V., Debré P., Haupt K., Tse Sum Bui B. Molecularly Imprinted Polymer Nanoparticles as Potential Synthetic Antibodies for Immunoprotection against HIV . ACS Appl. Mater. Interfaces2019, 11,9824-9831.
     ABSTRACT: We describe the preparation and characterization of synthetic antibodies based on molecularly imprinted polymer nanoparticles (MIP-NPs) for the recognition and binding of the highly conserved and specific peptide motif SWSNKS (3S), an epitope of the envelope glycoprotein 41 (gp41) of human immunodeficiency virus type 1 (HIV-1). This motif is implicated in the decline of CD4+ T cells and leads to the deterioration of the immune system during HIV infection. Therefore, the development of MIP-NPs that can target and block the 3S peptide to prevent subsequent cascade interactions directed toward the killing of CD4+ T cells is of prime importance. Because most antibodies recognize their protein antigen via a conformational or structured epitope (as opposed to a linear epitope commonly used for molecular imprinting), we employed protein molecular modeling to design our template epitope so that it mimics the three-dimensional structure fold of 3S in gp41. The resulting template peptide corresponds to a cyclic structure composed of CGSWSNKSC, with the 3S motif well orientated for imprinting. MIP-NPs with a size of 65 nm were obtained by solid-phase synthesis and were water-soluble. They were prepared by a judicious combination of multiple functional monomers affording hydrogen bonding, ionic, π–π, and hydrophobic interactions, conferring high affinity and selectivity toward both the cyclic peptide and the whole gp41 protein. These results suggest that our MIPs could potentially be used for blocking the function of the 3S motif on the virus.

Socrier L., Quero A., Verdu M., Song Y., Milinie R., Mathiron D., Pilard S., Mesnard F., Monrandat S. Flax phenolic compounds as inhibitors of lipid oxidation: Elucidation of their mechanisms of action. Food Chemistry2019, 274,651-658.
 

Monnier M., Furlan A., Botcazon C., Dahi A., Mongelard G., Cordelier S., Clement C., Dorey S., Sarazin C., Rippa S. Rhamnolipids from Pseudomonas aeruginosa are elicitors triggering Brassica napus protection against Botrytis cinerea without physiological disorders. Frontiers in Plant Science2018, 1778,101-124.
     ABSTRACT: Rhamnolipids (RLs) are amphiphilic molecules naturally produced by some bacteria with a large range of biological activities. Although some studies report their potential interest in plant protection, evaluation of their effects and efficiency on annual crops of worldwide agronomic interest is lacking. The main objective of this work was to investigate their elicitor and protective activities on rapeseed crop species while evaluating their physiological effects. Here we report that RLs from Pseudomonas aeruginosa secretome trigger an effective protection of Brassica napus foliar tissues toward the fungus Botrytis cinerea involving the combination of plant defense activation and direct antimicrobial properties. We demonstrated their ability to activate canonical B. napus defense responses including reactive oxygen species production, expression of defense genes, along with callose deposits and stomatal closure as efficient physical protections. In addition, microscopic cell death observations and electrolyte leakage measurements indicated that RLs trigger a hypersensitive response-like defense in this plant. We also showed that foliar spray applications of RLs do not induce deleterious physiological consequences on plant growth or chlorophyll content and that RL protective properties are efficient on several grown cultivars of rapeseed. To our knowledge, this is the first report of RLs as an elicitor that suppresses fungal disease on tissues of an annual crop species under greenhouse conditions. Our results highlight the dual mode of action of these molecules exhibiting plant protection activation and antifungal activities and demonstrate their potential for crop cultures as environmental-friendly biocontrol solution.

Jacques F., Rippa S., Perrin Y. Physiology of L-carnitine in plants in light of the knowledge in animals and microorganisms. Plant Science2018, 9,1170.
     ABSTRACT: L-carnitine is present in all living kingdoms where it acts in diverse physiological processes. It is involved in lipid metabolism in animals and yeasts, notably as an essential cofactor of fatty acid intracellular trafficking. Its physiological significance is poorly understood in plants, but L-carnitine may be linked to fatty acid metabolism among other roles. Indeed, carnitine transferases activities and acylcarnitines are measured in plant tissues. Current knowledge of fatty acid trafficking in plants rules out acylcarnitines as intermediates of the peroxisomal and mitochondrial fatty acid metabolism, unlike in animals and yeasts. Instead, acylcarnitines could be involved in plastidial exportation of de novo fatty acid, or importation of fatty acids into the ER, for synthesis of specific glycerolipids. L-carnitine also contributes to cellular maintenance though antioxidant and osmolyte properties in animals and microbes. Recent data indicate similar features in plants, together with modulation of signaling pathways. The biosynthesis of L-carnitine in the plant cell shares similar precursors as in the animal and yeast cells. The elucidation of the biosynthesis pathway of L-carnitine, and the identification of the enzymes involved, is today essential to progress further in the comprehension of its biological significance in plants.

Socrier L., Quero A., Verdu M., Song Y., Milinie R., Mathiron D., Pilard S., Mesnard F., Monrandat S. Flax phenolic compounds as inhibitors of lipid oxidation: Elucidation of their mechanisms of action. Food Chemistry2018, 1575,72-79.
 

Husson E., Auxenfans T., Herbaut M., Baralle M., Lambertyn V., Rakotoarivonina H., Remond C. & Sarazin C. Sequential and simultaneous strategies for biorefining of wheat straw using room temperature ionic liquids, xylanases and cellulases.. Bioresource Technol.2018, 251,280-287.
     ABSTRACT: Sequential and simultaneous strategies for fractioning wheat straw were developed in combining 1-ethyl-3-methyl imidazolium acetate [C2mim][OAc], endo-xylanases from Thermobacillus xylanilyticus and commercial cellulases. After [C2mim][OAc]-pretreatment, hydrolysis catalyzed by endo-xylanases of wheat straw led to efficient xylose production with very competitive yield (97.6?

Mehmood N., Alayoubi R., Husson E., Jacquard C., Buchs J., Sarazin C. & Gosselin I. Kluyveromyces marxianus, an attractive yeast for ethanolic fermentation in the presence of imidazolium ionic liquids.. Int. J. Molec. Sci.2018, 19,887.
     ABSTRACT: Imidazolium ionic liquids (ILs) are promising solvents for lignocellulosic biomass (LCB) pretreatment and allow the achievement of higher ethanolic yields after enzymatic hydrolysis and ethanolic fermentation. However, residual ILs entrapped in pretreated biomass are often toxic for fermentative microorganisms, but interaction mechanisms between ILs and cells are still unknown. Here we studied the effects of 1-ethyl-3-methylimidazolium acetate [Emim][OAc] and 1-ethyl-3-methylimidazolium methylphosphonate [Emim][MeO(H)PO2] on Kluyveromyces marxianus, a thermotolerant ethanologenic yeast. Morphological impacts induced by ILs on K. marxianus were characterized by Scanning Electron Microscopy analysis and showed wrinkled, softened, and holed shapes. In Yeast-Malt-Dextrose (YMD) medium, K. marxianus tolerated IL additions up to 2% for [Emim][OAc] and 6% for [Emim][MeO(H)PO2]. Below these thresholds, some IL concentrations enhanced ethanolic yields up to +34% by switching the metabolic status from respiratory to fermentative. Finally, K. marxianus fermentation was applied on several substrates pretreated with [Emim][OAc] or [Emim][MeO(H)PO2] and enzymatically hydrolyzed: a model long fiber cellulose and two industrial LCBs, softwood (spruce) and hardwood (oak) sawdusts. The maximum ethanolic yields obtained were 1.8 to 3.9 times higher when substrates were pretreated with imidazolium ILs. Therefore K. marxianus is an interesting fermentative yeast in a second-generation bioethanol process implying IL pretreatment

Tshabuse F., Farrant J. M., Humbert L., Moura D., Rainteau D., Espinasse C., Idrissi A., Merlier F., Acket S., Rafudeen M. S., Thomasset B. & Ruelland E. Glycerolipid analysis during desication and recovery of the resurrection plant Xerophyta humilis (Bak) Dur and Schinz.. Plant Cell Environ.2018, 41,533-547.
     ABSTRACT: Feelings in humans are mental states representing groups of physiological functions that usually have defined behavioural purposes. Feelings, being evolutionarily ancient, are thought to be coordinated in the brain stem of animals. One function of the brain is to prioritise between competing mental states and, thus, groups of physiological functions and in turn behaviour. Plants use groups of coordinated physiological activities to deal with defined environmental situations but currently have no known mental state to prioritise any order of response. Plants do have a nervous system based on action potentials transmitted along phloem conduits but which in addition, through anastomoses and other cross?links, forms a complex network. The emergent potential for this excitable network to form a mental state is unknown, but it might be used to distinguish between different and even contradictory signals to the individual plant and thus determine a priority of response. This plant nervous system stretches throughout the whole plant providing the potential for assessment in all parts and commensurate with its self?organising, phenotypically plastic behaviour. Plasticity may, in turn, depend heavily on the instructive capabilities of local bioelectric fields enabling both a degree of behavioural independence but influenced by the condition of the whole plant.

Xu J., Prost E., Haupt K. & Tse Sum Bui B. Direct and sensitive determination of trypsin in human urine using a water-soluble signaling fluorescent molecularly imprinted polymer nanoprobe. . Sensor. Actuat. B-Chem. 2018, 258,10-17.
     ABSTRACT: https://doi.org/10.1016/j.snb.2017.11.077

Maherani B., Wattraint O. Liposomal structure: A comparative study on light scattering and chromatography techniques. Journal of Dispersion Science and Technology2017, 38,1633-1639.
 

Azouzi S., Santuz H., Morandat S., Pereira C., Cote F., Hermine O., El Kirat K., Colin Y., Le Van Kim C., Etchebest C. & Amireault P. Antioxidant and membrane binding properties of serotonin protect lipids from oxidation.. Biophys. J.2017, 112,1863-1873.
     ABSTRACT: Serotonin (5-hydroxytryptamine, 5-HT) is a well-known neurotransmitter that is involved in a growing number of functions in peripheral tissues. Recent studies have shown nonpharmacological functions of 5-HT linked to its chemical properties. Indeed, it was reported that 5-HT may, on the one hand, bind lipid membranes and, on the other hand, protect red blood cells through a mechanism independent of its specific receptors. To better understand these underevaluated properties of 5-HT, we combined biochemical, biophysical, and molecular dynamics simulations approaches to characterize, at the molecular level, the antioxidant capacity of 5-HT and its interaction with lipid membranes. To do so, 5-HT was added to red blood cells and lipid membranes bearing different degrees of unsaturation. Our results demonstrate that 5-HT acts as a potent antioxidant and binds with a superior affinity to lipids with unsaturation on both alkyl chains. We show that 5-HT locates at the hydrophobic-hydrophilic interface, below the glycerol group. This interfacial location is stabilized by hydrogen bonds between the 5-HT hydroxyl group and lipid headgroups and allows 5-HT to intercept reactive oxygen species, preventing membrane oxidation. Experimental and molecular dynamics simulations using membrane enriched with oxidized lipids converge to further reveal that 5-HT contributes to the termination of lipid peroxidation by direct interaction with active groups of these lipids and could also contribute to limit the production of new radicals. Taken together, our results identify 5-HT as a potent inhibitor of lipid peroxidation and offer a different perspective on the role of this pleiotropic molecule.

Xu J, Haupt K. & Tse Sum Bui B. Core-shell molecularly imprinted polymer nanoparticles as synthetic antibodies in a sandwich fluoroimmunoassay for trypsin determination in human serum.. ACS Appl. Mater. Interfaces2017, 9, 24476?24483.
     ABSTRACT: We describe the application of a fluorescently labeled water-soluble core

Antonitti, V., Boudesoc, S., Dupont, L., Farvacques, N., Cezarda, C., Da Nascimento, S., Raimbert, J-f., Socrier, L., Robin, T-j., Morandat, S., El-kirat, K., Mullie, C., Sonnet, P. Synthesis, iron(III) complexation properties, molecular dynamics simulations and P. aeruginosa siderophore-like activity of two pyoverdine analogs. European Journal of Medicinal Chemistry2017, 137,338-350.
     ABSTRACT: P. aeruginosa ranks among the top five organisms causing nosocomial infections. Among the many novel strategies for developing new therapeutics against infection, targeting iron uptake mechanism seems promising as P.

Socrier L., Rosselin M., Durand G. & Morandat S. Cholesterol-nitrone conjugates as protective agents against lipid oxidation: A model membrane study. BBA-Biomembranes2017, 1859,2495-2504.
     ABSTRACT: Free radical scavengers such as ?-phenyl-N-tert-butylnitrone (PBN) have been widely used as protective agents in several biological models. We recently designed two PBN derivatives by adding a cholesterol moiety to the parent nitrone to increase its lipophilicity. In addition to the cholesterol, a sugar group was also grafted to enhance the hydrophilic properties at the same time. In the present work we report on the synthesis of a third derivative bearing only a cholesterol moiety and the physical chemical and antioxidant characterization of these three derivatives. We demonstrated they were able to form stable monolayers at the air/water interface and with the two derivatives bearing a sugar group, repulsive interactions with 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) were observed. We next investigated the interaction with DLPC on a liposome model. Fluorescence spectroscopy experiments showed the addition of a cholesterol moiety causes an ordering effect whereas the presence of the sugar group led to a disordering effect. The protective effect against lipid oxidation was then investigated using dynamic light scattering and the formation of conjugated dienes was quantified spectrophotometrically. Two oxidizing systems were tested, i.e. the AAPH-thermolysis which generates peroxyl radicals and the Fenton reagent which is responsible of the formation of hydroxyl radicals. Due to their membrane localization, the three cholesteryl-PBN derivatives are able to prevent lipid oxidation with the two types of radical inducers but with a different mode of action.

Merlier F., Jellali R., Leclerc E. Online monitoring of hepatic rat metabolism by coupling a liver biochip and a mass spectrometer. Analyst2017, 142,3747-3757.
     ABSTRACT: A microfluidic liver biochip was coupled with a mass spectrometer to detect in real time the drug metabolism of hepatocytes. The hepatocytes were cultivated in the biochip for 35 h. The biochip was placed in a small-scale incubator in which the temperature and CO2 concentration were controlled. The biochip was connected serially to a mass spectrometer, a peristaltic pump and a culture medium reservoir. The injection in the mass spectrometer was performed every 10 min for 11 h. The metabolism of midazolam, phenacetin, omeprazole, dextromethorphan, repaglinide, rosuvastatin, tolbutamide and caffeine was investigated. We monitored the apparition of omeprazole sulfone, hydroxy omeprazole, repaglinide glucuronide, rosuvastatin lactone, dextrorphan, 1-hydroxy midazolam, 4-hydroxy midazolam, 1,4-hydroxy midazolam, paracetamol and 1,3-methylxanthine. Although these were observed, hydroxytolbutamide, 3-methoxymorphinan and midazolam glucuronide, hydroxy repaglinide were not detected. Based on a pharmacokinetic model, we calculated in vitro intrinsic clearances in which adsorption onto the perfusion circuit was taken into account. Then, using a liver organ model, we extrapolated the in vitro intrinsic clearances to the in vivo clearances. The estimated in vivo clearances were in agreement with the literature data on rats for midazolam, dextromethorphan, phenacetin, tolbutamide and caffeine. Rosuvastatin, omeprazole and repaglinide prediction underestimated the in vivo data.

Veneziano R., Rossi C., Chenal A., Brenner C., Ladant D., Chopineau J. Synthesis and characterization of tethered lipid assemblies for membrane protein reconstitution. Biointerphases2017, 12,04E301.
     ABSTRACT: Biological membranes and their related molecular mechanisms are essential for all living organisms. Membranes host numerous proteins and are responsible for the exchange of molecules and ions, cell signaling, and cell compartmentation. Indeed, the plasma membrane delimits the intracellular compartment from the extracellular environment and intracellular membranes. Biological membranes also play a major role in metabolism regulation and cellular physiology (e.g., mitochondrial membranes). The elaboration of membrane based biomimetic systems allows us to reconstitute and investigate, in controlled conditions, biological events occurring at the membrane interface. A whole variety of model membrane systems have been developed in the last few decades. Among these models, supported membranes were developed on various hydrophilic supports. The use of solid supports enables the direct use of surface sensitive techniques (e.g., surface plasmon resonance, quartz crystal microbalance, and atomic force microscopy) to monitor and quantify events occurring at the membrane surface. Tethered bilayer membranes (tBLMs) could be considered as an achievement of the first solid supported membranes described by the McConnell group. Tethered bilayers on solid supports were designed to delimit an inside compartment from an outside one. They were used for measuring interactions with ligands or incorporating large membrane proteins or complexes without interference with the support. In this context, the authors developed an easy concept of versatile tBLMs assembled on amino coated substrates that are formed upon the vesicle fusion rupture process applicable to protein-free vesicles as well as proteoliposomes. The phospholipid bilayer (natural or synthetic lipids) incorporated 5% of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly ethylene glycol-N-hydroxy succinimide to ensure the anchorage of the bilayer to the amino coated surface. The conditions for the formation of tBLMs on amino-coated gold and glass were optimized for protein-free vesicles. This biomimetic membrane delimits an inside

Brahim M., Checa Fernandez B. L., Regnier O., Bousseta N., Grimi N., Sarazin C., Husson E., Vorobiev E., Brosse N. Impact of ultrasounds and high voltage electrical discharges on physico-chemical properties of rapeseed straw’s lignin and pulps. Bioresource Technology2017, 237,42308
  

Acket S., Degournay A., Merlier F. & Thomasset B. Data documenting the comparison between the theoretically expected values of free sugars mass isotopomer composition with standards using GC-MS and LC-HRMS for Metabolic Flux Analysis.. Data in Brief2017, 12,108-112.
     ABSTRACT: The data presented in this article are related to the research article entitled

Hodrogue A., Trecherel E., Cornu M., Darwiche W., Mansour A., Ait-mohand K., Verissimo T., Gomila C., Schembri C., Da Nascimento S., Elboutachfait R., Boulier A., Lorne E., Courtois J., Petit E., Toumieux S., Kovensky J., Sonnet P., Massy Z. A., Kamel S. Rossi C., Ausseil J. Oligogalacturonic acid inhibits vascular calcification by two mechanisms: inhibition of VSMC osteogenic conversion and interaction with collagen. Arteriosclerosis, Thrombosis, and Vascular Biology2017, 37,1391-1401.
 

Hano C., Corbin C., Quero A., Rombaut N., Savoire R., Molinie R., Thomasset B., Mesnard F. & Laine E. The use of (+)-secoisolariciresinol extracted from the hulles as en effective protectant of linseed oil and its emulsion against oxidative damage. . Eur. J. Lipid Sci. Technol2017, 118,
  

Aimee Rasolohery C., Ermenegilde Ralaiba B., Ayerdi Gotor A., Merlier F., Benja R., Rakotovao M., Rhazi L. Chemical Characterization and Antioxidant Potential of Athroisma protei- formis Essential Oil. The Natural Products Journal2017, 7,208-215.
 

Hano C., Corbin C., Drouet S., Quero A., Rombaut N., Savoire R., MoliniÉ R., Thomasset B., Mesnard F., LainÉ E. The lignan (+)-secoisolariciresinol extracted from flax hulls is an effective protectant of linseed oil and its emulsion against oxidative damage . Eur. J. Lipid Sci. Technol. 2017, 119,1600219.
     ABSTRACT: Secoisolariciresinol (SECO) is a natural antioxidant lignan accumulated in large amounts in the seedcoat of flax and retained in the flaxseed cake residue during linseed oil pressing. Here SECO was extracted and purified from flaxseed cake and assayed for its ability to prevent oxidation of linseed oil and an o/w emulsion containing linseed oil. For this purpose, an accelerated storage (Schaal oven) test was performed and SECO effectiveness was compared to that of two antioxidants commonly used in food and cosmetic products: ??tocopherol (??TOCO) and butylated hydroxyanisole (BHA). In our hands, SECO addition, ranging from 50 to 500??mole per kg oil, significantly decreased the production of both primary (conjugated dienes, CD) and secondary (thiobarbituric acid?reactive substances, TBARS) oxidation products. This study evidenced that SECO is an effective stabilizer of linseed oil and its o/w emulsion and this protective effect outperformed both the natural ??TOCO and the synthetic BHA antioxidants. In particular, SECO was the most effective in the protection of the o/w emulsion against secondary oxidation products, which makes it a potential alternative preservative for oily products in foods and cosmetics.

Auxenfans T., Husson E. & Sarazin C. Simultaneous pretreatment and enzymatic saccharification of (ligno)celluloses in aqueous-ionic liquid media: a compromise.. Biochem. Eng. J.2017, 117,77-86.
     ABSTRACT: In view of decreasing the amount of IL to achieve efficient simultaneous pretreatment and saccharification, a comprehensive study was undertaken. Different types of lignocellulosic biomasses were investigated in various enzymatic aqueous-IL systems including 1-ethyl-3-methylimidazolium acetate ([C2mim][OAc]) or 1-ethyl-3-methylimidazolium methylphosphonate ([C2mim][MeO(H)PO2]). To better understand how 10% (v/v) of IL in the reaction medium led to the highest yields of glucose without fractionation from sawdust, distinct cellulosic models were then used as substrates. Kinetic studies demonstrated that both ILs affect synergistic action of cellulolytic enzymes depending on both constitutive anion and cellulosic substrate. Concentrations above 10% v/v of ILs deactivated cellulase even on highly digestible model substrates. ? and ? Kamlet-Taft parameters constituted more physicochemical pertinent indicators than apparent pH value to investigate effects of IL on cellulase performances. Fine description of these effects was proposed onto individual EG, CBH and BG. [C2mim][MeO(H)PO2] was demonstrated a better compatible IL for enzymes up to a concentration of 30% (v/v). The efficiency of simultaneous pretreatment and saccharification was governed by a compromise between better substrate accessibility and enzyme deactivation.

Shahsavarian M., Chaaya N., Costa N., Boquet D., Atkinson A., Offmann B., Kaveri Sv., Lacroix-desmazes S., Friboulet A., Avalle B. & Padiolleau-lefevre S. Multi-target selection of catalytic antibodies wih . FEBS J.2017, 284,634-653.
     ABSTRACT: ??lactamase enzymes responsible for bacterial resistance to antibiotics are among the most important health threats to the human population today. Understanding the increasingly vast structural motifs responsible for the catalytic mechanism of ??lactamases will help improve the future design of new generation antibiotics and mechanism?based inhibitors of these enzymes. Here we report the construction of a large murine single chain fragment variable (scFv) phage display library of size 2.7 ? 109 with extended diversity by combining different mouse models. We have used two molecularly different inhibitors of the R?TEM ??lactamase as targets for selection of catalytic antibodies with ??lactamase activity. This novel methodology has led to the isolation of five antibody fragments, which are all capable of hydrolyzing the ??lactam ring. Structural modeling of the selected scFv has revealed the presence of different motifs in each of the antibody fragments potentially responsible for their catalytic activity. Our results confirm (a) the validity of using our two target inhibitors for the in vitro selection of catalytic antibodies endowed with ??lactamase activity, and (b) the plasticity of the ??lactamase active site responsible for the wide resistance of these enzymes to clinically available inhibitors and antibiotics.

Panagiotopoulou M., Kunath S., Medina-rangel P. X., Haupt K. & Tse Sum Bui B. Fluorescent molecularly imprinted polymers as plastic antibodies for selective labeling and imaging of hyaluronan and sialic acid on fixed and living cells.. Biosens. Bioelectron.2017, 88,85-93.
     ABSTRACT: Altered glycosylation levels or distribution of sialic acids (SA) or hyaluronan in animal cells are indicators of pathological conditions like infection or malignancy. We applied fluorescently-labeled molecularly imprinted polymer (MIP) particles for bioimaging of fixed and living human keratinocytes, to localize hyaluronan and sialylation sites. MIPs were prepared with the templates D-glucuronic acid (GlcA), a substructure of hyaluronan, and N-acetylneuraminic acid (NANA), the most common member of SA. Both MIPs were found to be highly selective towards their target monosaccharides, as no cross-reactivity was observed with other sugars like N-acetyl-D-glucosamine, N-acetyl-D-galactosamine, D-glucose and D-galactose, present on the cell surface. The dye rhodamine and two InP/ZnS quantum dots (QDs) emitting in the green and in the red regions were used as fluorescent probes. Rhodamine-MIPGlcA and rhodamine-MIPNANA were synthesized as monodispersed 400 nm sized particles and were found to bind selectively their targets located in the extracellular region, as imaged by epifluorescence and confocal microscopy. In contrast, when MIP-GlcA and MIP-NANA particles with a smaller size (125 nm) were used, the MIPs being synthesized as thin shells around green and red emitting QDs respectively, it was possible to stain the intracellular and pericellular regions as well. In addition, simultaneous dual-color imaging with the two different colored QDs-MIPs was demonstrated. Importantly, the MIPs were not cytotoxic and did not affect cell viability; neither was the cells morphology affected as demonstrated by live cell imaging. These synthetic receptors could offer a new and promising imaging tool to monitor disease progression.

Ramsay A., Fliniaux O., Quero A., Molinie R., Demailly H., Hano C., Paetz C., Roscher A., Grand E., Kovensky J., Schneider B. & Mesnard F. Kinetics of the incorporation of the main phenolic compounds into the lignan macromolecule during flaxseed development.. Food Chem.2017, 217,1-8.
 

Buchoux S. FATSLiM: a fast and robust software to analyze MD simulations of membranes.. Bioinformatics2017, 33,133-154.
 

Quero A., Molinie R., Mathiron D., Thiombiano B., Fontaine J. F., Brancourt D., Van Wuytswinkel O., Petit E., Demailly H., Mongelard G., Pilard S., Thomasset B. & Mesnard F. Metabolite profiling in developing Camelina sativa seeds.. Metabolomics2016, 12,186-199.
 

Nestora S., Merlier F., Prost E., Haupt K., Rossi C. & Tse Sum Bui B. Solid-phase extraction of betanin and isobetanin from beetroot extracts using a dipicolinic acid molecularly imprinted polymer.. J. Chromatogr. A2016, 1465,47-54.
 

Canfarotta F., Waters A., Sadler R., Mcgill P., Guerreiro A., Papkovsky D., Haupt K. & Piletsky S. Biocompatibility and internalization of moleculary imprinted nanoparticles.. Nano Res.2016, 9,3463-3477.
 

Chia Gomez L. P., Spangenberg A., Ton X. A., Fuchs Y., Bokeloh F., Malval J. P., Tse Sum Bui B., Thuau D., Ayela C., Haupt K. & Soppera O. Rapid prototyping of chemical microsensors based on molecularly imprinted polymers synthesized by two-photon stereolithography.. Adv. Mater.2016, 28,5931-5937.
 

Parlak O., Beyazit S., Jafari M. J., Tse Sum Bui B., Haupt K., Tiwari A. & Turner A. P. F. Light-triggered switchable graphene-polymer hybrid bioelectronics.. Adv. Mater. Interfaces2016, 3,1500353.
 

Panagiotopoulou M., Salinas Y., Beyazit S., Kunath S., Mayes A. G., Duma L., Prost E., Resmini M., Tse Sum Bui B. & Haupt K. Molecularly imprinted polymer-coated quantum dots for multiplexed cell targeting and imaging.. Angew. Chem. Int. Ed.2016, 55,8244-8248.
 

Nestora S., Merlier F., Beyazit S., Prost E., Duma L., Baril B., Graves A., Haupt K. & Tse Sum Bui B. Plastic antibodies for cosmetics: Molecularly imprinted polymers scavenge precursors of malodors. . Angew. Chem. Int. Ed.2016, 55,6252-6256.
 

Tanvir S., Thuroczy G., Selmaoui B., Pires Antonietti V. S., Sonnet P., Arnaud-cormos D., Leveque P., Pulvin S. & De Seze R. Effects of 3G cell phone exposure on the structure and function of the human cytochrome P450 reductase.. Bioelectrochem.2016, 111,62-69.
 

Xu J. J., Ambrosini S., Tamahkar E., Rossi C., Haupt K. & Tse Sum Bui B. Toward a universal method for preparing molecularly imprinted polymer nanoparticles with antibody-like affinity for proteins.. Biomacromolecules2016, 17,345-353.
 

Jellali R., Bricks T., Jacques S., Fleury M. J., Paullier P., Merlier F. & Leclerc E. Long term human primary hepatocyte cultures in a microfluidic liver biochip show maintenance of mRNA levels and higher drugs metabolisms when compared to Petri cultures.. Biopharm. Drug Disp.2016, 37,264-275.
 

Bonomi P., Attieh M. D., Gonzato C. & Haupt K. A novel versatile water soluble iniferter platform for the preparation of imprinted nanoparticles via photopolymerization in aqueous media.. Chem.-Eur. J.2016, 22,10150-10154.
 

Mahendra A., Peyron I., Thaunat O., Dollinger C., Gilardin L., Sharma M., Wootla B., Rao D. N., Padiolleau-lefevre S., Boquet D., More A., Varadarajan N., Kaveri S. V., Legendre C. & Lacroix-desmazes S. Generation of catalytic antibodies is an intrinsic property of an individual's immune system: a study on a large cohort of renal transplant patients.. J. Immunol.2016, 196,4075-4081.
 

Saha C., Das M., Stephen-victor E., Friboulet A., Bayry J. & Kaveri S. Differential effect of Viscum album preparations on the maturation and activation of human dendritic cells and CD4+ T cell responses.. Molecules2016, 21,912.
 

Parlak O., Beyazit S., Tse Sum Bui B., Haupt K., Turner A. P. F. & Tiwari A. Programmable bioelectronics in a stimuli-encoded 3D graphene interface.. Nanoscale2016, 8,9976-9981.
 

Nguyen P. J., Rippa S., Rossez Y. & Perriny. Acylcarnitines participate in developmental processes associated to lipid metabolism in plants.. Planta2016, 243,1011-1022.
 

Beyazit S., Tse Sum Bui B., Haupt K. & Gonzato C. Molecularly imprinted polymer nanomaterials and nanocomposites by controlled/living radical polymerization.. Prog. Polym. Sci.2016, 62,1-21.
 

Kunath S., Panagiotopoulou M., Maximilien J., Marchyk N., Sanger J. & Haupt K. Cell and tissue imaging with molecularly imprinted polymers as plastic antibody mimics.. Adv. Healthc. Mater.2015, 4,1322-1326.
 

Adali-kaya Z., Tse Sum Bui B., Falcimaigne-cordin A. & Haupt K. Molecularly imprinted polymer nanomaterials and nanocomposites: atom-transfer radical polymerization with acidic monomers.. Angew. Chem. Int. Ed.2015, 54,192-195.
 

Azouzi S., El Kirat K. & Morandat S. Hematin loses its membranotropic activity upon oligomerization into malaria pigment.. Biochim. Biophys. Acta2015, 1848,2952-2959.
 

Starok M., Preira P., Vayssade M., Haupt K., Salome L. & Rossi C. EGFR inhibition by curcumin in cancer cells: a dual mode of action.. Biomacromolecules2015, 16,1634-1642.
 

Bricks T., Hamon J., Fleury M. J., Jellali R., Merlier F., Herpe Y. E., Seyer A., Regimbeau J. M., Bois F. & Leclerc E. Investigation of omeprazole and phenacetin frist-pass metabolism in humans using a microscale bioreactor and pharmacokinetic models.. Biopharm. Drug Disp.2015, 36,275-293.
 

Nowacki L., Follet J., Vayssade M., Vigneron P., Cambay F., Egles C. & Rossi C. Real-time QCM-D monitoring of cancer cell death events in a dynamic context.. Biosens. Bioelectron.2015, 64,469-476.
 

Ton X. A., Acha V., Bonomi P., Tse Sum Bui B. & Haupt K. A disposable evanescent wave fiber optic sensor coated with a molecularly imprinted polymer as a selective fluorescent probe.. Biosens. Bioelectron.2015, 64,359-366.
 

Mehmood N., Husson E., Jacquard C., Wewetzer S., Buchs J., Sarazin C. & Gosselin I. Impact of two ionic liquids, 1-ethyl-3-methylimidazolium acetate and 1-ethyl-3-methylimidazolium methylphosphonate, on Saccharomyces cerevisiae: metabolic, physiologic, and morphological investigations.. Biotechnol. Biofuels 2015, 8,n.17.
 

Fabre G., Bayach I., Berka K., Paloncyova M., Starok M., Rossi C., Duroux J. L., Otyepka M. & Trouillas P. Synergism of antioxidant action of vitamins E and Quercetin is related to formation of molecular associations in biomembranes.. Chem. Commun.2015, 51,7713-7716.
 

Bonnet V., Gervaise C., Djedaini-pilard F., Furlan A. & Sarazin C. Cyclodextrin nanoassemblies: a promising tool for drug delivery.. Drug. Discov. Today2015, 20,1120-1126.
 

Rombaut N., Savoire R., Thomasset B., Castello J. & Van Hecke E. Optimization of oil yield and oil total phenolic content during grape seed cold screw pressing.. Ind. Crops Prod.2015, 63,26-33.
 

Lazouk M. A., Savoire R., Kaddour A., Castello J., Lanoiselle J. L., Van Hecke E. & Thomasset B. Oilseeds sorption isoterms, mechanical properties and pressing.: Global view of water impact.. J. Food Eng.2015, 153,73-80.
 

Hulin L., Husson E., Bonnet J. P., Stevanovic T. & Sarazin C. Enzymatic transesterification of kraft lignin with long acyl chains in ionic liquids.. Molecules2015, 20,16334-16353.
 

Savoire R., Lazouk M. A., Van-hecke E., Roulard R., Tavernier R., Guillot X., Rhazi L., Petit E., Mesnard F. & Thomasset B. Environmental and varietal impact on linseed composition and on oil unidirectional expression process.. OCL2015, 22,D605.
 

Nowacki L., Vigneron P., Rotellini L., Cazzola H., Merlier F., Prost E., Ralanairina R., Gadonna J. P., Rossi C. & Vayssade M. Betanin-enriched red beetroot (Beta vulgaris L.) extract induces apoptosis and autophagic cell death in MCF-7 cells.. Phytother. Res.2015, 29,1964-1973.
 

Saha C., Hegde P., Friboulet A., Bayry J. & Kaveri S. V. Viscum album-mediated COX-2 inhibition implicates destabilization of COX-2 mRNA.. PloS One2015, 10,e114965.
 

Panagiotopoulou M., Beyazit S., Nestora S., Haupt K., & Tse Sum Bui B. Initiator-free synthesis of molecularly imprinted polymers by polymerization of self-initiated monomers.. Polymer2015, 66,43-51.
 

Bompart M., Goto A., Wattraint O., Sarazin C., Tsujii Y., Gonzato C. & Haupt K. Molecularly imprinted polymers by reversible chain transfer catalyzed polymerization.. Polymer2015, 78,31-36.
 

Foguel M. V., Ton X. A., Zanoni M. V. B., Sotomayor M. D. P. T., Haupt K. & Tse Sum Bui B. A molecularly imprinted polymer-based evanescent wave fiber optic sensor for the detection of basic red 9 dye. . Sens. Actuators B2015, 218,222-228.
 

Elluru S. R., Saha C., Hedge P., Friboulet A., Bayry J. & Kaveri S. Dissecting the anti-inflammatory effects of Viscum album: inhibition of cytokine-induced expression of cyclooxygenase-2 and secretion of prostaglandin E2.. Translat. Res. Biomed.2015, 4,67-73.
 

Ponomarenko N., Chatziefthimiou S. D., Kurkova I., Mokrushina Y., Stepanova A., Smirnov I., Avakyan M., Bobik T., Mamedov A., Mitkevich V., Belogurov A., Fedorova O., Dubina M., Golovin A., Lamzin V., Friboulet A., Makarov A., Wilmanns M. & Gabibov A. Role of . Acta Crystallogr. D2014, 70,708-719.
 

Fuchs Y., Kunath S., Soppera O., Haupt K. & Mayes A. G. Molecularly imprinted silver-halide reflection holograms for label-free opto-chemical sensing.. Adv. Funct. Mater.2014, 24,688-694.
 

Ayela C., Dubourg G., Pellet C. & Haupt K. All-organic micromechanical systems integrating specific molecular recognition. A new generation of chemical sensors.. Adv. Mater.2014, 26,5876-5879.
 

Boultadakis-arapinis M., Gandon V., Prost E., Micouin L. & Lecourt T. Electronic effects in carbene-mediated C-H bond functionalization: an experimental and theoretical study.. Adv. Synth. Catal.2014, 356,2493-2505.
 

Beyazit S., Ambrosini S., Marchyk N., Palo E., Kale V., Soukka T., Tse Sum Bui B. & Haupt K. Versatile synthetic strategy for coating upconverting nanoparticles with polymer shells through localized photopolymerization by using the particles as internal light sources.. Angew. Chem. Int. Ed.2014, 53,8919-8923.
 

Furlan A., Jobin M. L., Buchoux S., Grelard A., Dufourc E. & Gean J. Membrane lipids protected from oxidation by red wine tannins: a proton NMR study.. Biochimie2014, 107,82-90.
 

Auxenfans T., Buchoux S., Husson E. & Sarazin C. Efficient enzymatic saccharification of Miscanthus: energy-saving by combinig dilute acid and ionic liquid pretreatments.. Biomass Bioenerg.2014, 62,82-92.
 

Prot J. M., Maciel L., Bricks T., Merlier F., Cotton J., Paullier P., Bois F. & Leclerc E. First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans.. Biotechnol. Bioeng.2014, 111,2027-2040.
 

Padiolleau-lefevre S., Ben Naya R., Shahsavarian M., Friboulet A. & Avalle B. Catalytic antibodies and their applications in biotechnology: State of the art.. Biotechnol. Lett.2014, 36,1369-1379.
 

Rombaut N., Savoire R., Thomasset B., Belliard T., Castello J., Van Hecke E. & Lanoiselle J. L. Grape seed oil extraction: interest of supercritical fluid extraction and gas assisted mechanical extraction for enhancing polyphenol co-extraction in oil.. C.R. Chimie2014, 17,284-292.
 

Ortial S., Morandat S., Bortolato M., Roux B., Polidori A., Pucci B. & Durand G. PBN derived amphiphilic spin-traps. II/ Study of their antioxidant properties in biomimetic membranes.. Colloids Surf. B2014, 113,384-393.
 

Auxenfans T., Buchoux S., Larcher T., Husson G., Husson E. & Sarazin C. Enzymatic saccharification and structural properties of industrial wood sawdust: recycled ionic liquids pretreatments.. Energ. Convers. Manage.2014, 88,1094-1103.
 

Gervaise C., Bonnet V., Nolay F., Cezard C., Stasik I., Sarazin C. & Djedaini-pilard F. Diesterification of 3-[(ß-cyclodextrinyl)succinamido]propane-1,2-diol catalyzed by lipase: Diastereoselectivity or tridimensional substrate specificity?. Eur. J. Org. Chem.2014, 2014,6200-6209.
 

Shahsavarian M., Le Minoux D., Matti K. M., Kaveri S., Lacroix-desmazes S., Boquet D., Friboulet A., Avalle B. & Padiolleau-lefevre S. Exploitation of rolling circle amplification for the construction of large phafe display antibody libraries.. J. Immunol. Methods2014, 407,26-34.
 

Sharma M., Lecerf M., Friboulet A., Kaveri S. V., Dissous C. & Bayry J. Dendritic cells but not basophils mediate Th17 responses to Schistosomes.. J. Infect. Dis.2014, 209,2019-2021.
 

Li B., Xu J., Hall A. J., Haupt K. & Tse Sum Bui B. Water-compatible silica sol-gel molecularly imprinted polymer as potential delivery system for the controlled release of salicylic acid.. J. Mol. Recognit.2014, 27,559-565.
 

Ramsay A., Fliniaux O., Fang J., Molinie R., Roscher A., Grand E., Guillot X., Kovensky J., Fliniaux M. A., Schneider B. & Mesnard F. Development of an NMR metabolomics-based tool for selection of flaxseed varieties.. Metabolomics2014, 10,1258-1267.
 

Koubaa M., Thomasset B. & Roscher A. Quantifying 13C-label in free sugars and starch by GC-MS.. Methods Molec. Biol.2014, 1090,121-130.
 

Roscher A., Troufflard S. & Taghki A. I. In vivo NMR for (13)C metabolic flux analysis.. Methods Molec. Biol.2014, 1090,143-152.
 

Fliniaux O., Corbin C., Ramsay A., Renouard S., Beejmohun V., Doussot J., Falguieres A., Ferroud C., Lamblin F., Laine E., Roscher A., Grand E., Mesnard F. & Hano C. Microwave-assisted extraction of herbacetin diglucoside from flax (Linum usitatissimum L.) seed cakes and its quantification using RP-HPLC-UV system.. Molecules2014, 19,3025-3037.
 

Marchyk N., Maximilien J., Beyazit S., Haupt K. & Tse Sum Bui B. One-pot synthesis of iniferter-bound polystyrene core nanoparticles for the controlled grafting of multilayer shells.. Nanoscale2014, 6,2872-2878.
 

Gonzato C., Pasetto P., Bedoui F., Mazeran P. E. & Haupt K. On the effect of using RAFT and FRP for the bulk synthesis of acrylic and methacrylic molecularly imprinted polymers.. Polymer Chem.2014, 5,1313-1322.
 

Bricks T., Paullier P., Legendre A., Fleury M. J., Zeller P., Merlier F., Anton P. M. & Leclerc E. Development of a new microfluidic platform integrating co-cultures of intestinal and liver cell lines.. Toxicol. In Vitro2014, 28,885-895.
 

Vidal G., Blanchi T., Mieszawska A. J., Calabrese R., Rossi C., Vigneron P., Duval J. L., Kaplan D. L. & Egles C. Enhanced cellular adhesion on titanium by silk functionalized with titanium binding and RGD peptides.. Acta Biomater.2013, 9,4935-4943.
 

Cakir P., Cutivet A., Resmini M., Tse Sum Bui B. & Haupt K. Protein-size molecularly imprinted polymer nanogels as synthetic antibodies, by localized polymerization with multi-initiators.. Adv. Mater.2013, 25,1048-1051.
 

Fuchs Y., Soppera O., Mayes A. G. & Haupt K. Holographic molecularly imprinted polymers for label-free chemical sensing.. Adv. Mater.2013, 25,566-570.
 

Morandat S., Azouzi S., Beauvais E., Mastouri A. & El Kirat K. Atomic force microscopy of model lipid membranes.. Anal. Bioanal. Chem.2013, 405,1445-1461.
 

Koubaa M., Cocuron J. C., Thomasset B. & Alonso A. Highlighting the tricarboxylic acid cycle : liquid and gas chromatography-mass spectrometry analyses of 13C-labeled organic acids.. Anal. Biochem.2013, 436,151-159.
 

Ton X. A., Tse Sum Bui B., Resmini M., Bonomi P., Dika I., Soppera O. & Haupt K. A versatile fiber-optic fluorescence sensor based on molecularly imprinted microstructures polymerized in situ.. Angew. Chem. Int. Ed.2013, 52,8317-8321.
 

Ben Naya R., Matti K., Guellier A., Matagne A., Boquet D., Thomas D., Friboulet A., Avalle B. & Padiolleau-lefevre S. Efficient refolding of a recombinant abzyme: Structural and catalytic characterizations.. Appl. Microbiol. Biotechnol.2013, 97,7721-7731.
 

Crosson C. & Rossi C. Quartz crystal microbalance immunosensor for the quantification of Immunoglobulin G in bovine milk.. Biosens. Bioelectron.2013, 42,453-459.
 

Chantreau M., Grec S., Gutierrez L., Dalmais M., Pineau C., Demailly H., Paysant-leroux C., Tavernier R., Trouve J. P., Chatterjee M., Guillot X., Brunaud V., Chabbert B., Van Wuytswinkel O., Bendahmane A., Thomasset B. & Hawkins S. PT-Flax (phenotyping and TILLing of flax): development of a flax (Linum usitatissimum L.) mutant population and TILLing platform for forward and reverse genetics.. BMC Plant Biol.2013, 13,159-174.
 

Fenart S., Chabi M., Gallina S., Huis R., Neutelings G., Riviere N., Thomasset B., Hawkins S. & Lucau-danila A. Intra-platform comparison of 25-mer and 60-mer oligonucleotide Nimblegen DNA microarrays.. BMC Res. Notes2013, 6,43.
 

Smirnov I., Belogurov A., Friboulet A., Masson P., Gabibov A. G. & Renard P. Y. Strategies for the selection of catalytic antibodies against organophosphorus nerve agents.. Chem-Biol. Interact.2013, 203,196-201.
 

Ambrosini S., Beyazit S., Haupt K. & Tse Sum Bui B. Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition.. Chem. Commun.2013, 49,6746-6748.
 

Almant M., Mastouri A., Gallego-yerga L., Garcia-fernandez J. M., Ortiz-mellet C., Kovensky J., Morandat S., El Kirat K. & Gouin S. G. Probing th nature of the cluster effect observed with synthetic multivalent galactosides and PNA lectin.. Chem.-Eur. J.2013, 19,729-738.
 

Zdunek J., Benito-pena E., Linares A., Falcimaigne-cordin A., Orellana G., Haupt K. & Moreno-bondi M. C. Surface-imprinted nanofilaments for Europium-amplified luminescent detection of fluoroquinolones antibiotics.. Chem.-Eur. J.2013, 19,10209-10216.
 

Chaveriat L., Gosselin I., Machut C. & Martin P. Synthesis, surface tension properties and antibacterial activities of amphiphilic D-galactopyranose derivatives.. Eur. J. Med. Chem.2013, 62,177-186.
 

Belogurov A. A., Stepanov A. V., Smirnov I. V., Melamed D., Bacon A., Mamedov, A. E., Boltsov V. M., Sashchenko L. P., Ponomarenko N. A., Sharanova S. N., Boyko A. N., Dubina M. V., Friboulet A., Genkin D. D. & Gabibov A. G. Liposome-encapsulated peptides protect against experimental allergic encephalitis.. FASEB J. 2013, 27,222-231.
 

Doyen A., Husson E. & Bazinet L. Use of an electrodialytic reactor for the simultaneous ß-lactoglobulin enzymatic hydrolysis and fractionation of generated bioactive peptides.. Food Chem.2013, 136,1193-1202.
 

Husson E., Araya-farias M., Dejardins Y. & Bazinet L. Selective anthocyanins enrichment of cranberry juice by electrophoresis with multiple ultrafiltration membranes stacked.. Innov. Food Sci. Emerg. Technol. 2013, 17,153-162.
 

Wattraint O., Saadallah I., Silva-peres V., Sonnet P. & Sarazin C. Influence of the insertion of a cationic peptide on the size and shape of nanoliposomes: a light scattering investigation.. Int. J. Pharm.2013, 454,621-624.
 

Brissonnet Y., Ortiz-mellet C., Morandat S., Garcia-moreno M. I., Deniaud D., Matthews S. E., Vidal S., Sestak S., El Kirat K. & Gouin S. G. Topological effects and binding modes operating with multivalent imino-sugar-based glycoclusters and mannosidases.. J. Am. Chem. Soc.2013, 135,18427-18435.
 

Bonnet V., Favrelle A., Aubry F., Sarazin C. & Djedaini-pilard F. Solvent-free chemo-enzymatic synthesis of fatty acyl-bcyclodextrin.. J. Incl. Phenom. Macrocycl. Chem.2013, 77,155-161.
 

Husson E., Araya-farias M., Gagne A. & Bazinet L. Selective anthocyanins enrichment of cranberry juice by electrodialysis with filtration membranes: influence of membrane characteristics.. J. Membrane Sci.2013, 448,114-124.
 

Dmitrienko E. V., Bulushev R. D., Haupt K., Kosolobov S. S., Latyshev A. V., Pyshnaya I. A. & Pyshnyi D. V. A simple approach to prepare molecularly imprinted polymers from nylon-6.. J. Mol. Recognit.2013, 26,368-375.
 

Fang J., Ramsay A., Paetz C., Tatsis E. C., Renouard S., Hano C., Grand E., Fliniaux O., Roscher A., Mesnard F. & Schneider B. Concentration kinetics of secoisolariciresinol diglucoside and its biosynthetic precursor coniferin in developing flaxseed.. Phytochem. Anal.2013, 24,41-46
  

Kantarovich K., Tsarfati-barad I., Gheber L. A., Haupt K. & Bar I. Reading biochips by raman and surface-enhanced raman spectroscopies.. Plasmonics2013, 8,3-12.
 

Mahendra A., Peyron I., Dollinger C., Gilardin L., Sharma M., Wootla B., Padiolleau-lefevre S., Friboulet A., Boquet D., Legendre C., Kaveri S., Thaunat O. & Lacroix-desmazes S. IVIg treatment reduces catalytic antibody titers of renal transplanted patients.. PloS One2013, 8,e70731.
 

Veneziano R., Rossi C., Chenal A., Devoiselle J. M., Ladant D. & Chopineau J. Bordetella pertussis Adenylate Cyclase Toxin Translocation across a Tethered Lipid Bilayer.. Proc. Natl. Acad. Sci. USA2013, 110,20473-20478.
 

Kunath S., Marchyk N., Haupt K. & Feller K. H. Multi-objective optimization and design of experiments as tools to tailor molecularly imprinted polymers specific for glucuronic acid.. Talanta2013, 105,211-218.
 

Koubaa M., Mghaieth S., Thomasset B. & Roscher A. Gas chromatography-mass spectrometry analysis of 13C labeling in sugars for metabolic flux analysis.. Anal. Biochem.2012, 425,183-188.
 

Fuchs Y., Soppera O. & Haupt K. Photopolymerization and photostructuring of molecularly imprinted polymers for sensor applications-A review.. Anal. Chim. Acta2012, 717,7-20.
 

Gervaise C., Bonnet V., Wattraint O., Aubry F., Sarazin C., Jaffres P. A. & Djedaini-pilard F. Synthesis of lipophosphoramidyl-cyclodextrins and their supramolecular properties.. Biochimie2012, 94,66-74.
 

Ton X. A., Acha V., Haupt K. & Tse Sum Bui B. Direct fluorimetric sensing of UV-excited analytes in biological and environmental samples using molecularly imprinted polymer nanoparticles and fluorescence polarization.. Biosens. Bioelectron.2012, 36,22-28.
 

Mahendra A., Padiolleau-lefevre S., Kaveri S. & Lacroix-desmazes S. Do proteolytic antibodies complete the panopply of the autoimmune response in acquired haemophilia A?. Br. J. Haematol.2012, 156,3-12.
 

Auxenfans T., Buchoux S., Djellab K., Avondo C., Husson E. & Sarazin C. Mild pretreatment and enzymatic saccharification of cellulose with recycled ionic liquid towards one-batch process.. Carbohydr. Polym.2012, 90,805-813.
 

Bernier M. C., El Kirat K., Besse M., Morandat S. & Vayssade M. Preosteoblasts and fibroblasts respond differently to anastase titanium dioxide nanoparticles: a cytotoxicity and inflammatory study.. Colloids Surf. B2012, 90,68-74.
 

Dufourc E. J., Buchoux S., Toupe J., Sani M. A., Jean-francois F., Khemtemourian L., Grelard A., Loudet_courreges C., Laguerre M., Elezgaray J., Desbat B. & Odaert B. Membrane interacting peptides: from killers to helpers.. Curr. Prot. Pept. Sci.2012, 13,620-631.
 

Rosant C., Avalle B., Larcher D., Dupont A., Friboulet A. & Tarascon J. M. Biosynthesis of electrode nanomaterials by phage engineering: comprehension and future.. Energ. Environ. Sci.2012, 5,9936-9943.
 

Tanvir S., Oudet F., Pulvin S. & Anderson W. A. Coenzyme based synthesis of silver nanocrystals.. Enzyme Microbiol. Technol.2012, 51,231-236.
 

Doumiati S., Haupt K. & Rossi C. Autophosphorylation activation and inhibition by curcumin of the epidermal growth factor receptor reconstituted in liposomes.. J. Mol. Recognit.2012, 25,623-629.
 

Tanvir S., Merlier F. & Pulvin S. Biosensing of reactive intermediates produced by the photocatalytic activities of titanium dioxide nanoparticles.. J. Photochem. Photobiol. B2012, 110,22-27.
 

Bernier M. C., Besse M., Vayssade M., Morandat S. & El Kirat K. Titanium dioxide nanoparticles disturb the fibronectin-mediated adhesion and spreading of pre-osteoblastic cells.. Langmuir2012, 28,13660-13667.
 

Boussetta N., Vorobiev E., Le L. H., Cordin-falcimaigne A. & Lanoiselle J. L. Application of electrical treatments in alcoholic solvent for polyphenols extraction from grape seeds.. LWT-Food Sci. Technol.2012, 46,127-134.
 

Le Minoux D., Mahendra A., Lacroix-desmazes S., Limnios N., Friboulet A., Avalle B., Boquet D., Kaveri S. & Padiolleau-lefevre S. A novel molecular analysis of genes encoding catalytic antibodies.. Mol. Immunol.2012, 50,160-168.
 

Gervaise C., Bonnet V., Sarazin C. & Djedaini-pilard F. Synthesis of glycerolipidyl derivatives of permethylated b-cyclodextrin as potential nanovectors.. New J. Chem.2012, 36,2417-2424.
 

Rippa S., Zhao Y., Merlier F., Charrier A. & Perrin Y. The carnitine biosynthetic pathway in Arabidopsis thaliana shares similar features with the pathway of mamals and fungi.. Plant Physiol. Biochem.2012, 60,109-114.
 

Charrier A., Rippa S., Yu A., Nguyen P. J., Renou J. P. & Perrin Y. The effect of carnitine on Arabidopsis development and recovery in salt stress conditions.. Planta2012, 235,123-135.
 

Biffis A., Dvorakova G. & Falcimaigne-cordin A. Physical forms of MIPS.. Top. Curr. Chem.2012, 325,29-82.
 

Bompart M., Haupt K. & Ayela C. Micro and nanofabrication of molecularly imprinted polymers.. Top. Curr. Chem.2012, 325,83-110.
 

Haupt K., Linares A. V., Bompart M. & Tse Sum Bui B. Molecularly imprinted polymers.. Top. Curr. Chem.2012, 325,1-28.
 

Gonzato C., Courty M., Pasetto P. & Haupt K. Magnetic molecularly imprinted polymer nanocomposites via surface-initiated RAFT polymerization.. Adv. Funct. Mater.2011, 21,3947-3953.
 

Maddur M. S., Hegde P., Sharma M., Kaveri S. V. & Bayry J. B cells are resistant to immunomodulation by "IVIg-educated" dendritic cells.. Autoimmun. Rev.2011, 11,154-156.
 

Fadel O., El Kirat K. & Morandat S. The natural antioxidant rosmarinic acid spontaneously penetrates membranes to inhibit lipid peroxidation in situ.. Biochim. Biophys. Acta2011, 1808,2973-2980.
 

Husson E., Buchoux S., Avondo C., Cailleu D., Djellab K., Gosselin I., Wattraint O. & Sarazin C. Enzymatic hydrolysis of ionic liquid-pretreated celluloses: contribution of CP-MAS, 13C NMR and SEM.. Bioresource Technol.2011, 102,7335-7342.
 

Pilalis E., Chatziioannou A., Thomasset B. & Kolisis F. An In-silico compartmentalized, metabolic model of Brassica napus, enables the systemic study of regulatory aspects of plant central metabolism.. Biotechnol. Bioeng.2011, 108,1673-1682.
 

Wootla B., Christophe O., Mahendra A., Dimitrov J., Repesse Y., Ollivier V., Friboulet A., Borel-derlon A., Levesque H., Borg J. Y., Andre S., Bayry J., Calvez T., Kaveri S. & Lacroix-desmazes S. Proteolytic antibodies activate factor IX in patients with acquired hemophilia. Blood2011, 117,2257-2264.
 

Fuchs Y., Linares A. V., Mayes A. G., Haupt K. & Soppera O. Ultrathin selective molecularly imprinted polymer microdots obtained by evanescent wave photopolymerization.. Chem. Mater.2011, 23,3645-3651.
 

Servant A., Haupt K. & Resmini M. Tuning molecular recognition in water-soluble nanogels with enzyme-like activity for Kemp elimination.. Chem.-Eur. J.2011, 17,11052-11059.
 

Morandat S. & El Kirat K. Cytochrome c provokes the weakening of zwitterionic membranes as measured by force spectroscopy.. Colloids Surf. B2011, 82,111-117.
 

Harz S., Shimmelpfennig M., Tse Sum Bui B., Marchyk N., Haupt K. & Feller K. H. Fluorescence optical spectrally resolved sensor based on molecularly imprinted polymers and microfluidics.. Eng. Life Sci.2011, 11,559-565.
 

Gabibov A. G., Belogurov A. A., Lomakin Y. A., Zakharova M. Y., Avakyan M. E., Dubrovskaya V. V., Smirnov I. V., Ivanov A. S., Molnar A. A., Gurtsevitch V. E., Diduk S. V., Smirnova K. V., Avalle B., Sharanova S. N., Tramontano A., Friboulet A., Boyko A. N., Ponomarenko N. A. & Tikumova N. V. Combinatorial antibody library from Multiple Sclerosis patients reveals antibodies that cross-react with myelin basic protein and EBV-antigen.. FASEB J.2011, 25,4211-4221.
 

Boussetta N., Vorobiev E., Deloison V., Pochez F., Falcimaigne-cordin A. & Lanoiselle J. L. Valorisation of grape pomace by the extraction of phenolic antioxidants: Application of high voltage electrical discharges.. Food Chem.2011, 128,364-370.
 

Tse Sum Bui B. & Haupt K. Preparation and evaluation of a molecularly imprinted polymer for the selective recognition of testosterone – application to molecularly imprinted sorbent assays.. J. Mol. Recognit.2011, 24,1123-1129.
 

Diot J. D., Moreno I. G., Twigg G., Ortiz Mellet C., Haupt K., Butters T. D., Kovensky J. & Gouin S. G. Amphiphilic 1-deoxynojirimycin derivatives through click strategies for chemical chaperoning in N370S Gaucher cells.. J. Org. Chem.2011, 76,7757-7768.
 

Azouzi S., Morandat S. & El Kirat K. The potent antimalarial peptide cyclosporin a induces the aggregation and permeabilization of sphingomyelin-rich membranes.. Langmuir2011, 27,9465-9472.
 

Piperno S., Tse Sum Bui B., Haupt K. & Ghebert L. A. Immobilization of molecularly imprinted polymer nanoparticles in electrospun poly(vinyl alcohol) nanofibers.. Langmuir2011, 27,1547-1550.
 

Zakharov A. V., Smirnov I. V., Serebryakova M. V., Dronina M. A., Kaznacheeva A. V., Kurkova I. N., Belogurov A. A., Friboulet A., Ponomarenko N. A., Gabibov A. G. & Bobik T. V. Expression of catalytic antibodies in eukaryotic systems. Mol. Biol.2011, 45,74-81.
 

Hegde P., Maddur M., Friboulet A., Bayry J. & Kaveri S. Viscum album exerts anti-inflammatory effect by selectively inhibiting cytokine-induced expression of cyclooxygenase-2.. PloS One2011, 6,e26312.
 

Prot J. M., Briffaut A. S., Letourneur F., Chafey P., Merlier F., Grandvalet Y., Legallais C. & Leclerc E. Integrated proteomic and transcriptomic investigation of the acetaminophen toxicity in liver microfluidic biochip.. PloS One2011, 6,e21268.
 

Rossi C., Doumiati S., Lazzarelli C., Davi M., Meddar F., Ladant D. & Chopineau J. A tethered bilayer assembled on top of immobilized calmodulin to mimic cellular compartmentalization.. PloS One2011, 6,e19101.
 

Stepanov A. V., Belogurov A. A., Ponomarenko N. A., Stremkovskly O. A., Kozlov L. V., Bichucher A. M., Dmitriev S. E., Shatsky I. N., Smirnov I. V., Shamborant O. G., Tonevitsky A. G., Friboulet A., Gabibov A. G. & Deyev S. M. Design of targeted B-cell killing agents.. PloS One2011, 6,e20991.
 

Zhendre V., Grelard A., Garnier-lhomme M., Buchoux S., Larijani B. & Dufourc E. J. Key role of polyphosphoinositides in dynamics of fusogenic nuclear membrane vesicles.. PloS One2011, 6,e23859.
 

Smirnov I., Carletti E., Kurkova I., Nachon F., Nicolet Y., Mitkevich V., Debat H., Avalle B., Belogurov A., Kuznetsov N., Reshetnyak A., Masson P., Tonevitsky A., Ponomarenko N., Makarov A. A., Friboulet A., Tramontano A. & Gabibov A. G. Reactibodies generated by kinetic selection couple chemical reactivity with faborable protein dynamics.. Proc. Natl. Acad. Sci. USA2011, 108,15954-1959.
 

Linares A. V., Falcimaigne-cordin A., Gheber L. A. & Haupt K. Patterning nanostructured, synthetic, polymeric receptors by simultaneous projection photolithography, nanomolding, and molecular imprinting.. Small2011, 7,2318-2325.
 

Bompart M., De Wilde Y. & Haupt K. Chemical nanosensors based on composite molecularly imprinted polymer particles and surface-enhanced Raman scattering.. Adv. Mater.2010, 22,2343-2348.
 

Tse Sum Bui B. & Haupt K. Molecularly imprinted polymers : synthetic receptors in bioanalysis. Anal. Bioanal. Chem.2010, 398,2481-2492.
 

Tse Sum Bui B., Merlier F. & Haupt K. Towards the use of a molecularly imprinted polymer in doping analysis :selective preconcentration and analysis of testosterone and epitestosterone in human urine.. Anal. Chem.2010, 82,4420-4427.
 

El Kirat K., Morandat S. & Dufrene Y. F. Nanoscale analysis of supported lipid bilayers using atomic force microscopy.. Biochim. Biophys. Acta2010, 1798,750-765.
 

Kantarovich K., Tsarfati I., Gheber L. A., Haupt K. & Bar I. Reading microdots of a molecularly imprinted polymer by surface-enhanced Raman spectroscopy.. Biosens. Bioelectron.2010, 26,809-814.
 

Fenart S., Ndong Y. P., Duarte J., Riviere N., Van Wuytswinkel O., Lucau A., Cariou E., Neutelings G., Gutierrez L., Chabbert B., Guillot X., Tavernier R., Hawkins S. & Thomasset B. Development and validation of a flax (Linum usitatissinum L.) gene expression oligo microarray.. BMC Genomics2010, 11,592.
 

Rippa S., Eid M., Formaggio F., Toniolo C & Beven L. Hypersensitive-like response to the pore-former peptaibol alamethicin in Arabidopsis thaliana. Chembiochem2010, 11,2042-2049.
 

Largueze J. B., El Kirat K. & Morandat S. Preparation of an electrochemical biosensor based on lipid membranes in nanoporous alumina.. Colloids Surf. B2010, 79,33-40.
 

Bonnet V., Gervaise C., Favrelle A., Sarazin C. & Djedaini-pilard F. Enzymatic catalysis in presence of cyclodextrins.. Curr. Org. Chem.2010, 14,1323-1336.
 

Jousse C., Schiltz S., Fournez A., Guillot X., Thomasset B., Gougeon S., Bourgaud F. & Gontier E. Rapid, cost-effective screening of flax genotypes to identify desirable fatty acid compositions.. Electron. J. Plant Breed.2010, 1,1396-1404
  

Phichith D., Bun S., Padiolleau-lefevre S., Guellier A., Banh S., Gallieni M., Frere J. M., Thomas D., Friboulet A. & Avalle B. Novel peptide inhibiting both TEM-1 beta-lactamase and penicillin-binding proteins.. FEBS J.2010, 277,4965-4972.
 

Brique A., Devassine J., Pilard S., Cailleu D. & Gosselin I. Osmoregulated trehalose-derived oligosaccharides in Sinorhizobium meliloti.. FEBS Letters2010, 584,3661-3666.
 

Dehkharghanian M., Adenier H. & Vijayalakshmi M. A. Study of flavonoids in aqueous spinach extract using positive electrospray ionisation tandem quadrupole mass spectrometry.. Food Chem.2010, 121,863-870.
 

Crosson C., Thomas D. & Rossi C. Quantification of immunoglobulin G in bovine and caprine milk using a surface plasmon resonance–based immunosensor.. J. Agr. Food Chem.2010, 58,3259-3264.
 

Batchelor R., Windle C. J., Buchoux S. & Lorch M. Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers.. J. Biol. Chem.2010, 285,41402-41411.
 

Eid M., Rippa S., Castano S., Desbat B., Chopineau J. Rossi C. & Beven L. Exploring the membrane mechanism of the bioactive peptaibol ampullosporin A using lipid monolayers and supported biomimetic membranes. J. Biophys.2010, 2010,Art.ID 179641.
 

Favrelle A., Bonnet V., Avondo C., Aubry F., Djedaini-pilard F. & Sarazin C. Lipase-catalyzed synthesis and characterization of novel lipidyl-cyclodextrins in solvent free medium.. J. Mol. Catal. B.2010, 66,224-227.
 

Lalo H., Ayela C., Dague E., Vieu C. & Haupt K. Nanopatterning molecularly imprinted polymers by soft lithography: a hierarchical approach.. Lab Chip2010, 10,1316-1318.
 

Azouzi S., El Kirat K. & Morandat S. The potent antimalarial drug cyclosporin A preferentially destabilizes sphingomyelin-rich membranes.. Langmuir2010, 26,1960-1965.
 

Haupt K. Plastic antibodies.. Nature Mater.2010, 9,612-614.
 

Laveille P., Falcimaigne A., Chamouleau F., Renard G., Drone J., Fajula F., Pulvin S., Bedel-cloutour C., Thomas D., Bailly C. & Galarneau A. Hemoglobin immobilized on mesoporous silica as effective material for the removal of polycyclic aromatic hydrocarbons pollutants from water.. New J. Chem.2010, 34,2153-2165.
 

Claude B., Viron-lamy C., Haupt K. & Morin P. Synthesis of a molecularly imprinted polymer for the solid-phase extraction of betulin and betulinic acid from plane bark.. Phytochem. Anal.2010, 21,180-185.
 

Essono S., Clement G., Padiolleau-lefevre S., Creminon C., Grassi J. & Boquet D. Peptide mass assisted antibody cloning strategy for accurate characterization of potential therapeutic monoclonal antibodies against neurodegenerative diseases.. Prot. Eng. Des. Select.2010, 23,203-210.
 

Linares A. V., Vandevelde F., Pantigny J., Falcimaigne-cordin A. & Haupt K. Polymer films composed of surface-bound nanofilaments with a high aspect ratio, molecularly imprinted with small molecules and proteins.. Adv. Funct. Mater.2009, 19,1299-1303.
 

Kantarovich K., Tsarfati I., Gheber L. A., Haupt K. & Bar I. Writing droplets of molecularly imprinted polymers by nano fountain pen and detecting their molecular interactions by surface-enhanced Raman scattering.. Anal. Chem.2009, 81,5686-5690.
 

Elluru S. R., Duong Van Huyen J. P., Delignat S., Prost F., Heudes D., Kazatchkine M. D., Friboulet A. & Kaveri S. V. Antiangiogenic properties of viscum album extracts are associated with endothelial cytotoxicity.. Anticancer Res.2009, 29,2945-2950
  

Kantarovich K., Belmont A. S., Haupt K., Bar I. & Gheber L. A. Detection of template binding to molecularly imprinted polymers by Raman spectroscopy.. Appl. Phys. Lett.2009, 94,194103.
 

Bompart M. & Haupt K. Molecularly imprinted polymers and controlled/living radical polymerization.. Aust. J. Chem.2009, 62,751-761.
 

Lotierzo M., Tse Sum Bui B., Leech H. K., Warren M. J., Marquet A. & Rigby S. E. J. Iron-sulfur cluster dynamics in biotin synthase: A new [2Fe-2S]1+ cluster.. Biochem. Biophys. Res. Commun. 2009, 381,487-490.
 

Kouzayha A., Wattraint O. & Sarazin C. Interactions of two transmembrane peptides in supported lipid bilayers studied by a 31P and 15N MAOSS NMR strategy.. Biochimie2009, 91,774-778.
 

Nlandu Mputu M., Rhazi L., Vasseur G., Vu T. D., Gontier E. & Thomasset B. Identification of a potential bottleneck in branched chain fatty acid incorporation into triacylglycerol for lipid biosynthesis in agronomic plants.. Biochimie2009, 91,703-710.
 

Octave S. &thomas D. Biorefinery: Toward an industrial metabolism.. Biochimie2009, 91,659-664.
 

Vockenroth I. K., Rossi C., Raza Sha M. & Koper I. Formation of tethered bilayer lipid membranes probed by various surface sensitive techniques.. Biointerphases2009, 4,19-26.
 

Bompart M., Geher L. A., De Wilde Y. & Haupt K. Direct detection of analyte binding to single molecularly imprinted polymer particles by confocal Raman spectroscopy.. Biosens. Bioelectron.2009, 25,568-571.
 

El Kirat K., Bartkowski M. & Haupt K. Probing the recognition specificity of a protein molecularly imprinted polymer using force spectroscopy.. Biosens. Bioelectron.2009, 24,2618-2624.
 

Pasetto P., Flavin K. & Resmini M. Simple spectroscopic method for titration of binding sites in molecularly imprinted nanogels with hydrolase activity.. Biosens. Bioelectron.2009, 25,572-578
  

Laveille P., Galarneau A., Drone J., Fajula F., Bailly C., Pulvin S. & Thomas D. Catalase-like activity of bovine met-hemoglobin: interaction with the pseudo-catalytic peroxidation of anthracene traces in aqueous medium.. Biotechnol. J.2009, 4,1460-1470.
 

El Kirat K. & Morandat S. Cytochrome c interaction with neutral lipid membranes: influence of lipid packing and protein charges.. Chem. Phys. Lipids2009, 162,17-24.
 

Wootla B., Desirazu N. R., Friboulet A., Uda T., Lacroix-desmazes S. & Kaveri S. V. Varied immune response to FVIII: Presence of proteolytic antibodies directed to Factor VIII in different human pathologies.. Clin. Rev. Allerg. Immunol.2009, 37,97-104.
 

Tanvir S., Pantigny J., Morandat S. & Pulvin S. Development of immobilization technique for liver microsomes.. Colloids Surf. B2009, 68,178-183.
 

Kurkova I. N., Reshetnyak A. V., Durova O. M., Knorre V. D., Tramontano A., Friboulet A., Ponomarenko N. A., Gabibov A. G. & Smirnov I. V. Antibodes-antidotes against organophosphorus compounds?. Dokl. Biochem. Biophys.2009, 425,94-97.
 

Landoulsi J., Dagbert C., Richard C., Sabot R., Jeannin M., El Kirat K. & Pulvin S. Enzyme-induced ennoblement of AISI 316L stainless steel: Focus on pitting corrosion behavior.. Electrochim. Acta2009, 54,7401-7406.
 

Tanvir S., Adenier H. & Pulvin S. Screening and prediction of reactive intermediates in a microreactor with immobilized rat hepatic microsomes using acetaminophen as a model drug. . Enzyme Microbiol. Technol.2009, 45,112-117.
 

Wootla B., Mahendra A., Dimitrov J. D., Friboulet A., Borel-derlon A., Rao D. N., Uda T., Borg J. Y., Bayry J., Kaveri S. V. & Lacroix-desmazes S. Factor VIII-hydrolyzing IgG in acquired and congenital hemophilia.. FEBS Letters2009, 583,2565-2572.
 

Boussetta N., Lebovka N., Vorobiev E., Adenier H., Bedel Cloutour C. & Lanoiselle J. L. Electrically assisted extraction of soluble matter from chardonnay grape skins for polyphenol recovery.. J. Agr. Food Chem.2009, 57,1491-1497.
 

Cutivet A., Schembri C., Kovensky J. & Haupt K. Molecularly imprinted microgels as enzyme inhibitors.. J. Am. Chem. Soc.2009, 131,14699-14702.
 

Mhaka B., Cukrowska E., Tse Sum Bui B., Ramstrom O., Haupt K., Tutu H. & Chimuka L. Selective extraction of triazine herbicide from food samples based on a combination of a liquid membrane and molecularly imprinted polymers.. J. Chromatogr. A2009, 1216,6796-6801.
 

Boussetta N., Lanoiselle J. L., Bedel-cloutour C. & Vorobiev E. Extraction of soluble matter from grape pomace by high voltage electrical discharges for polyphenol recovery: Effect of sulphur dioxide and thermal treatments.. J. Food Eng.2009, 95,192-198.
 

Shynkaryk M. V., Lebovska N. I., Lanoiselle J. L., Nonus M., Bedel-cloutour C. & Vorobiev E. Electrically-assisted extraction of bio-products using high pressure disruption of yeast cells (Saccharomyces cerevisiae).. J. Food Eng.2009, 92,189-195.
 

Tanvir S., Pantigny J., Boulnois P. & Pulvin S. Covalent immobilization of recombinant human cytochrome CYP2E1 and glucose-6-phosphate dehydrogenase in alumina membrane for drug screening applications.. J. Membrane Sci.2009, 329,85-90.
 

Kouzayha A., Nasir M. N., Buchet R., Wattraint O., Sarazin C. & Besson F. Conformational and interfacial analyses of K3A18K3 and alamethicin in model membranes.. J. Phys. Chem. B2009, 113,7012-7019.
 

Guillon S., Lemaire R., Linares A. V., Haupt K. & Ayela C. Single step patterning of molecularly imprinted polymers for large scale fabrication of microchips.. Lab Chip2009, 9,2987-2991.
 

Pasetto P., Blas H., Audouin F., Boissiere C., Sanchez C., Save M. & Charleux B. Mechanistic insight into surface-initiated polymerization of methylmetacrylate and styrene via ATRP from ordered mesoporous silica particles.. Macromolecules2009, 42,5983-5995
  

Lievre K., Tran T. L., Doerper S., Hehn A., Lacoste P., Thomasset B., Bourgaud F. & Gontier E. Agrobacterium-mediated transformation of Ruta graveciens L.. Methods Molec. Biol.2009, 547,235-248.
 

Durova O. M., Vorobiev I. I., Smirnov I. V., Reshetnyak A. V., Telegin G. B., Shamborant O. G., Orlova N. A., Genkin D. D., Bacon A., Ponomarenko N. A., Friboulet A. & Gabibov A. G. Strategies for induction of catalytic antibodies towards HIV-1 glycoprotein gp120 in autoimmune prone mice.. Mol. Immunol.2009, 47,87-95.
 

Phichith D., Bun S., Padiolleau-lefevre S., Banh S., Thomas D., Friboulet A. & Avalle B. Mutational and inhibitory analysis of a catalytic antibody. Implication for drug discovery.. Mol. Immunol.2009, 47,348-356.
 

Tanvir S., Morandat S., Nadaud F., Adenier H. & Pulvin S. Activity of immobilised rat hepatic microsomal CYP2E1 using alumina membrane as a support.. N. Biotechnol.2009, 26,222-228.
 

Diot J., Garcia-moreno M. I., Gouin S. G., Mellet C. O., Haupt K. & Kovensky J. Multivalent iminosugars to modulate affinity and selectivity for glycosidases.. Org. Biomol. Chem.2009, 7,357-363.
 

Labboun S., Terce-laforgue T., Roscher A., Bedu M., Restivo F. M., Velanis C. N., Skopelitis D. S., Moshou P. N., Roubelakis K. A., Suzuki A. & Hirel B. Resolving the role of plant glutamate dehydrogenase: I. In vivo real time nuclear magnetic resonance spectroscopy experiments.. Plant Cell Physiol.2009, 50,17761-1773.
 

Caillot S., Rosiau E., Laplace C. & Thomasset B. Influence of light intensity and selection scheme on regeneration time of transgenic flax plants.. Plant Cell Rep.2009, 28,359-371.
 

Picard N., Guenin S., Perrin Y., Hilaire G. & Larnicol N. Consequences of prenatal exposure to diazepam on the respiratory parameters, respiratory network activity and gene expression of a1 and alpha-2 subunits of GABA(A) receptor in newborn rat.. Adv. Exp. Biol. Med.2008, 605,144-148.
 

Tse Sum Bui B., Belmont A. S., Witters H. & Haupt K. Molecular recognition of endocrine disruptors by synthetic and natural 17beta-estradiol receptors: a comparative study.. Anal. Bioanal. Chem.2008, 390,2081-2088.
 

Elluru S. R., Vani J., Delignat S., Bloch M. F., Lacroix-desmazes S., Kazatchkine M. D., Kaveri S. V. & Bayry J. Modulation of human dendritic cell maturation and function by natural IgG antibodies.. Autoimmun. Rev.2008, 7,487-490.
 

Rohde M. & Stewart J. Ascriptional and "genuine" autonomy.. BioSystems2008, 9,424-433
  

Noizet M., Harrabi F., Vijayalakshmi M., Galbraith D., Thomas D. & Thomasset B. Targeted protein accumulation promoted by autoassembly and its recovery from plan cells.. Biotechnol. J.2008, 3,392-402.
 

Elluru S. R., Duong Van Huyen J. P., Delignat S., Kazatchkine M. D., Friboulet A., Kaveri S. V. & Bayry J. Induction of maturation and activation of human dendritic cells: A mechanism underlying the beneficial effect of Viscum album as complimentary therapy in cancer.. BMC Cancer2008, 8,161.
 

Bartholomeusz T. A., Molinie R., Mesnard F., Robins R. J. & Roscher A. Optimisation of 1D and 2D in vitro 1H NMR to study tropane alkaloid metabolism in Pseudomonas.. C.R. Chimie2008, 11,457-464.
 

Smirnov I. V., Vorobiev I. I., Friboulet A., Avalle B., Thomas D., Knorre V. D., Gabibov A. G. & Ponomarenko N. A. The antiidiotypic approach to obtaining a proteolytic antibody.. Dokl. Biochem. Biophys.2008, 420,105-107.
 

Landoulsi J., El Kirat K., Richard C., Sabot R., Jeannin M. & Pulvin S. Glucose oxidase immobilization on stainless steel to mimic the aerobic activities of natural biofilms.. Electrochim. Acta2008, 54,133-139.
 

Landoulsi J., El-kirat K., Richard C., Feron D. & Pulvin S. Enzymatic approach in microbial influenced corrosion : A review based on stainless steels in natural waters.. Env. Sci. Technol.2008, 42,2233-2242.
 

El Kirat K., Pardo-jacques A. & Morandat s. Interaction of non-ionic detergents with biomembranes at the nanoscale observed by atomic force microscopy,. Int. J. Nanotechnology2008, 5,769-783.
 

Vandevelde F., Pantigny J., Pezron I., Gheber L. & Haupt K. Nanostructured molecularly imprinted polymer films as synthetic recognition layers.. Int. J. Nanotechnology2008, 5,757-768.
 

Landoulsi J., Genet M. J., Richard C., El Kirat K., Pulvin S. & Rouxhet P. G. Evolution of the passive film and organic constituents at the surface of stainless steel immersed in fresh water.. J. Colloid Interf. Sci.2008, 318,278-289.
 

Landoulsi J., Genet M. J., Richard C., El Kirat K., Rouxhet P. G. & Pulvin S. Ennoblement of stainless steel in the presence of glucose oxidase: nature and role of interfacial processes.. J. Colloid Interf. Sci.2008, 320,508-519.
 

Belogurov A. A., Kurkova I. N., Friboulet A., Thomas D., Misikov V. K., Zakharova M. U., Suchkov S. V., Kotov V., Alexin A. I., Avalle B., Souslova E. A., Morse H. C., Gabibov A. G. & Ponomarenko N. A. Recognition and Degradation of Myelin Basic Protein Peptides by Serum Autoantibodies as a Novel Biomarker for Multiple Sclerosis.. J. Immunol.2008, 180,1258-1267.
 

Wootla B., Dasgupta S., Dimitrov J. D., Bayry J., Levesque H., Borg J. Y., Borel-derlon A., Rao D. N., Friboulet A., Kaveri S. V. & Lacroix-desmazes S. FVIII hydrolysis mediated by anti-FVIII autoantibodies in acquired hemophilia.. J. Immunol.2008, 180,7714-7720.
 

Wootla B., Nicoletti A., Patey N., Dimitrov J. D., Legendre C., Christophe O. D., Friboulet A., Kaveri S. V., Lacroix-desmazes S. & Thaunat O. Hydrolysis of coagulation factors by circulating IgG is associated with a reduced risk for chronic allograft nephropathy in renal transplanted patients.. J. Immunol.2008, 180,8455-8460.
 

Picard N., Guenin S., Perrin Y. & Larnicol N. Maternal caffeine ingestion during gestation and lactation influences respiratory adaptation to acute alveolar hypoxia in newborn rats and adenosine A2A and GABA A receptor mRNA transcription.. Neuroscience2008, 156,630-639.
 

Picard N., Guenin S., Perrin Y., Hilaire G. & Larnicol N. Prenatal diazepam exposure alters respiratory control system and Gabaa and adenosine receptor gene expression in newborn rats.. Pediatr. Res.2008, 64,44-49.
 

Claude B., Morin P., Lafosse M., Belmont A. S. & Haupt K. Selective solid-phase extraction of a triterpene acid from a plant extract by molecularly imprinted polymer.. Talanta2008, 75,344-350.
 

Favrelle A., Bonnet V., Sarazin C. & Djedaini-pilard F. Synthesis of polyenyl derivatives of permethylated beta-cyclodextrin.. Tetrahedron Asym.2008, 19,2240-2245.
 

Vandevelde F., Belmont A. S., Pantigny J. & Haupt K. Hierarchically nanostructured polymer films based on molecularly imprinted surface-bound nanofilaments.. Adv. Mater.2007, 19,3717-3720.
 

Rossi C. & Haupt K Application of the Doehlert experimental design to molecularly imprinted polymers: surface response optimization of specific template recognition as a function of the type and degree of cross-linking.. Anal. Bioanal. Chem.2007, 389,455-460.
 

Ayela C., Vandevelde F., Lagranfe D., Haupt K. & Nicu L. Combining resonant piezoelectric micromembranes with molecularly imprinted polymers.. Angew. Chem. Int. Ed.2007, 46,9271-9274.
 

Belmont A. S., Sokuler M., Haupt K. & Gheber L. A. Direct writing of molecularly imprinted microstructures using a nanofountain pen.. Appl. Phys. Lett.2007, 90,193101.
 

Ponomarenko N. A., Pillet D., Paon M., Vorobiev I. I., Smirnov I. V., Adenier H., Avalle B., Kolesnikov A. V., Kozyr A. V., Thomas D., Gabibov A. G. & Friboulet A. Anti-idiotypic antibody mimics proteolytic function of parent antigen.. Biochemistry 2007, 46,14598-14609.
 

El Kirat K. & Morandat S. Cholesterol modulation of membrane resistance to Triton X-100 explored by atomic force microscopy.. Biochim. Biophys. Acta2007, 1768,2300-2309.
 

Belmont A. S., Jaeger S., Knopp D., Niessner R., Gauglitz G. & Haupt K. Molecularly imprinted polymer films for reflectometric interference spectroscopic sensors.. Biosens. Bioelectron.2007, 22,3267-3272.
 

Rippa S, Adenier H, Derbaly M. And Beven L. The peptaibol alamethicin induces an rRNA-cleavage-associated death in Arabidopsis thaliana.. Chem. Biodivers.2007, 4,1360-1373.
 

Morandat S. & El Kirat K. Solubilization of supported lipid membranes by octyl glucoside observed by time-lapse atomic force microscopy.. Colloids Surf. B2007, 55,179-184.
 

Reshetnyak A. V., Armentano M. F., Morse H. C., Friboulet A., Makker S. P., Tramontano A., Knorre V. D., Gabibov A. G. & Ponomarenko N. A. Mechanism-dependent selection of immunoglobulin gene library for obtaining covalent biocatalysis.. Dokl. Biochem. Biophys.2007, 415,179-182.
 

Rossi C. & Chopineau J. Biomimetic tethered lipid membranes designed for membrane-protein interaction studies.. Eur. Biophys. J.2007, 36,955-965.
 

Reshetnyak A. V., Armentano M. F., Ponomarenko N. A., Durova O., Ziganshin R., Serebryakova M., Govorun V., Gololobov G., Morse H. C., Friboulet A., Makket S. P. Gabibov A. G. & Tramontano A. Route to covalent catalysis by reactive selection for nascent protein nucleophile.. J. Am. Chem. Soc.2007, 129,16175-16182.
 

Favrelle A., Bonnet V., Sarazin C. & Djedaini-pilard F. Novel chemo-enzymatic access to amphiphilic cyclodextrins. . J. Incl. Phenom. Macrocycl. Chem.2007, 57,15-20.
 

Rossi C., Briand E., Parot P., Odorico M. & Chopineau J. Surface response methodology for the study of supported membrane formation.. J. Phys. Chem. B2007, 111,7567-7576.
 

Deniaud A., Rossi C., Berquand A., Homand J., Campagna S., Knoll W., Brenner C. & Chopineau J. Voltage-dependent anion channel transports calcium ions through biomimetic membranes.. Langmuir2007, 23,3898-3905.
 

Morandat S. & El Kirat K. Real-time atomic force microscopy reveals cytochromec-induced alterations in neutral lipid bilayers.. Langmuir2007, 23,10929-10932.
 

Vandevelde F., Leichle T., Ayela C., Bergaud C., Nicu L. & Haupt K. Direct patterning of molecularly imprinted microdot arrays for sensors and biochips.. Langmuir2007, 23,6490-6493.
 

Troufflard S., Roscher A., Thomasset B., Barbotin J. N., Rawsthorne S. & Portais J. C. In vivo (13)C NMR determines metabolic fluxes and steady state in linseed embryos.. Phytochem.2007, 68,, 2341-2350.
 

Robins R. J., Molinie R., Kwiecien R. A., Paneth P., Lebreton J., Bartholomeusz T. A., Roscher A., Drager B. & Mesnard F. Progress in understanding the N-demethylation of alkaloids by exploiting isotopic techniques. . Phytochem. Rev.2007, 6,51-63.
 

Lelandais-briere C., Jovanovic M., Torres G. A., Perrin Y., Lemoine R., Corre-menguy F. & Hartmann C. Disruption of AtOCT1, an organic cation transporter gene, affects root development and carnitine-related responses in Arabidopsis.. Plant J.2007, 51,154-164.
 

Bourdin B., Adenier H. & Perrin Y. Carnitine is associated with fatty acid metabolism in plants.. Plant Physiol. Biochem.2007, 45,926-931.
 

Sineriz F., Ikeda Y., Petit E., Bultel L., Haupt K., Kovensky J. & Papy-garcia D. Toward an alternative for specific recognition of sulfated sugars. Preparation of highly specific molecular imprinted polymers.. Tetrahedron2007, 63,1857-1862.
 

Grafe A., Haupt K. & Mohr G. J. Optical sensor materials for the detection of amines in organic solvent. . Anal. Chim. Acta2006, 565,42-47.
 

Delattre C., Michaud P., Keller C., Elboutachfaiti R., Beven L., Courtois B. & Courtois J. Purification and characterization of a novel glucuronan lyase from Trichoderma sp GL2. . Appl. Microbiol. Biotechnol.2006, 70,437-443.
 

Ponomarenko N. A., Vorobiev I. I., Alexandrova E. S., Reshetnyak A. V., Telegin G. B., Khaidurov S. V., Avalle B., Karavanov A., Morse H. C., Thomas D., Friboulet A. & Gabibov A. G. Induction of protein-targeted catalytic response in autoimmune prone mice: antibody-mediated cleavage of HIV-1 glycoprotein gp120. . Biochemistry2006, 45,324-330.
 

Alamillo J. M., Monger W., Sola I., Garcia B., Perrin Y., Bestagno M., Burrone O. R., Plana-duran J., Enjuanes L., Lomonossoff G. P. & Garcia J. A. Use of virus vectors for the expression in plants of active full-length and single-chain anti-coronavirus antibodies. . Biotechnol. J.2006, 1,1103-1111.
 

Wootla B., Dasgupta S., Mallet V. O., Kazatchkine M. D., Nagaraja V., Friboulet A., Kaveri S. V. & Lacroix-desmazes S. Physiopathology of catalytic antibodies: the case for FVIII-hydrolyzing IgG. . Blood Coagul. Fibrin.2006, 17,229-234.
 

Bartholomeusz T. A., Mesnard F., Felpin F. X., Lebreton J., Robins R. J. & Roscher A. Optimised NMR detection of 13C-2H double labelling in small molecules. . C.R. Chimie2006, 9,514-519.
 

Houyou N., Pau-roblot C. & Roscher A. 15N relaxation and quantification of 15N labelled metabolites in cell extracts. . C.R. Chimie2006, 9,320-524.
 

Wattraint O. & Sarazin C. Static and MAS solid-state study of supported phospholipid bilayer cylindrically oriented. . C.R. Chimie2006, 9,408-412.
 

Hunt C. E., Pasetto P., Ansell R. J. & Haupt K. A fluorescence polarisation molecular imprint sorbent assay for 2,4-D : a non separation pseudo immunoassay. . Chem. Commun.2006, 16,1754-1756.
 

Padiolleau-lefevre S., Debat H., Phichith D., Thomas D., Friboulet A. & Avalle B. Expression of a functional scFv fragment of an anti-idiotypic antibody with a ß-lactam hydrolytic activity. . Immunol. Letters2006, 103,39-44.
 

Gutierrez L., Conejero G., Castelain M., GuÉnin S., Verdeil J. L., Thomasset B. & Van Wuytswinkel O. Identification of new gene expression regulators specifically expressed during plant seed maturation.. J. Exp. Bot.2006, 57,1919-1932.
 

Lacroix-desmazes S., Wootla B., Dasgupta S., Delignat S., Bayry J., Reinbold J., Hoebeke J., Saenko E., Kazatchkine M. D., Friboulet A., Christophe O., Nagaraja V. & Kaveri S. N. Catalytic IgG from patients with hemophilia A inactivate therapeutic factor VIII. . J. Immunol.2006, 177,1355-1363.
 

Pichon V. & Haupt K. Affinity separations on molecularly imprinted polymers with special emphasis on solid-phase extraction. . J. Liquid Chromatogr.2006, 29,989-1023.
 

Morandat S. & El Kirat K. Membrane resistance to Triton X-100 explored by real-time atomic force microscopy. . Langmuir2006, 22,5786-5791.
 

Ferreira J. S., Lozano R., Mondie S. & Friboulet A. Bifurcation analysis of a biochemical network. . Lecture Notes Contr. Inf.2006, 341,279-286.
 

Canizares M. C., Liu L., Perrin Y., Tsakiris E. & Lomonossoff G. P. A bipartite system for the constitutive and inducible expression in high levels of foreign proteins in plants. . Plant Biotechnol. J.2006, 4,183-193.
 

Monger W., Alamillo J. M., Sola I., Perrin Y., Bestagno M., Burrone O. R., Sabella P., Plana-duran J., Enjuanes L., Garcia J. A. & Lomonossoff G. P. An antibody derivative expressed from viral vectors passively immunizes pigs against transmissible gastroenteritis virus infection when supplied orally in crude plant extracts. . Plant Biotechnol. J.2006, 4,623-631.
 

Ponomarenko N. A., Durova O. M., Vorobiev I. I., Belogurov A. A., Telegin G. B., Suchkov S. V., Misikov V. K., Kiselev S. L., Lagarkova M. A., Govorun V. M., Serebryakova M. V., Avalle B., Tornatore P., Karavanov A., Morse H. C., Thomas D., Friboulet A. & Gabibov A. G. Autoantibodies to myelin basic protein catalyze site specific degradation of their antigen. . Proc. Natl. Acad. Sci. USA2006, 103,281-286.
 

BOOK

Bokeloh F., Ayela C. & Haupt K. Micro and nanofabrication of molecularly imprinted polymers . Molecularly Imprinted Polymers for Analytical Chemistry Applications 2018, W. Kutner and P. Sindhu Sharma,pp. 167-197
  

Xu J, Medina-rangel P. X., Haupt K. & Tse Sum Bui B. Guide to the preparation of molecularly imprinted polymer nanoparticles for protein recognition, by solid-phase synthesis. Methods Enzymol2017, ,pp.115-141
  

Panagiotopoulou M., Kunath S., Haupt K., Tse Sum Bui B. Cell and Tissue Imaging with Molecularly Imprinted Polymers . Methods in Molecular Biology2017, ,PP.399-415
  

Saha C., Stephen-victor E., Friboulet A., Bayry J. & Kaveri S. V. Viscum album and its anti-inflammatory effect: angle of cytokine induced selective inhibition of COX-2.. Die Mistel in der Tumortherapie 42016, S. Scheer, A. Alban et al. eds.,pp. 197-203
  

Chavelot I, Arab-tehrany E, Husson E, Gerardun C, Vandamme E, Luis Revuelta J. Application of carnosine and its functionalised derivatives. Industrial Biotechnology of vitamins, biopigments, and antioxidants 2016, E.J. Vandamme & J.L. Revuelta eds. ,pp. 421-444
  

Maximilien J., Beyazit S., Rossi C., Haupt K. & Tse Sum Bui B Nanoparticles in biomedical applications. Measuring Biological impacts of nanomaterials2016, Springer International Publishing, Switzerland,pp. 177-210
  

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A. Friboulet, B. Avalle-bihan, H. Débat, D. Thomas Composés capables de moduler l'activité et de stimuler la production d'un anticorps catalytique. France, n° 01067542001, ,.